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Feature Article

Single-molecule covalent magnetic tweezers

Soham Chakraborty, Shubhasis Haldar

Trends in Biochemical Sciences (Technology of the month)

May, 2023


Single-molecule force spectroscopy (SMFS) technology enables us to study the heterogeneous nature of the biomolecules that are otherwise inaccessible by conventional ensemble approaches. In particular, magnetic tweezers, a widely-used SMFS technology, exert magnetic force and torque on the single biomolecules and allows us to study their dynamic changes and interactions.

Recent Publications

Please click on the graphics to find the articles.


Pan-cancer analyses suggest kindlin-associated global mechanochemical alterations

Debojyoti Chowdhury; Ayush Mistry; Debashruti Maity; Riti Bhatia; Shreyansh Priyadarshi; Simran Wadan; Soham Chakraborty; Shubhasis Haldar Communications Biology (IF: 6.35); 2024



Deep Chaudhuri, Souradeep Banerjee, Soham Chakraborty, Debojyoti Chowdhury, Shubhasis Haldar; BIOMACROMOLECULES (IF: 7); 2022



Structurally different chemical chaperones show similar mechanical roles with independent molecular mechanisms

Shubhasis Haldar, Deep Chaudhuri, DEBOJYOTI CHOWDHURY, Soham Chakraborty, Madhu Bhatt, Ayush Mistry, Aakashdeep Dutta; NANOSCALE (IF: 6.7); 2024


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Soham Chakraborty, Deep Chaudhuri, Dyuti Chaudhuri, Vihan Singh, Souradeep Banerjee, Debojyoti Chowdhury, Shubhasis Haldar; NANOSCALE (IF: 8.3); 2022



Ayush Chandrakant Mistry, Debojyoti Chowdhury, Soham Chakraborty, Shubhasis Haldar; Trends in Biochemical Sciences (IF: 14.3); 2023



Soham Chakraborty, Deep Chaudhuri, Souradeep Banerjee, Madhu Bhatt, Shubhasis Haldar; Nature Communications Biology (IF: 6.4); 2022



Souradeep Banerjee, Ritika Nara, Soham Chakraborty, Debojyoti Chowdhury, Shubhasis Haldar; Frontiers in Cell and Developmental Biology (IF: 6.7); 2022




Force-regulated chaperone activity of BiP/ERdj3 is opposite to their homologs DnaK/DnaJ: explained by strain energy

S Haldar, S Banerjee, D Chowdhury, S Chakraborty

bioRxiv, 2023.03. 16.532907


Methotrexate-modulated talin-dynamics drives cellular mechanical phenotypes via YAP signalling

D Chowdhury, S Dhabal, M Bhatt, D Maity, S Chakraborty, S Priyadarshi, S Haldar

bioRxiv, 2023.04. 07.535979


Other selected articles

DsbA is a redox-switchable mechanical chaperone

EC Eckels, D Chaudhuri, S Chakraborty, DJ Echelman, S Haldar

Chemical Science 12 (33), 11109-11120

Protein folding modulates the chemical reactivity of a Gram-positive adhesin

Alvaro Alonso-Caballero, Daniel J Echelman, Rafael Tapia-Rojo, Shubhasis Haldar, Edward C Eckels, Julio M Fernandez

Nature Chemistry 13 (2), 172-181

Cutting-edge single-molecule technologies unveil new mechanics in cellular biochemistry

Souradeep Banerjee, Soham Chakraborty, Abhijit Sreepada, Devshuvam Banerji, Shashwat Goyal, Yajushi Khurana, Shubhasis Haldar

Annual Review of Biophysics 50, 419-445

Force-directed “Mechanointeractome” of talin–integrin

S Chakraborty, S Banerjee, M Raina, S Haldar

Biochemistry 58 (47), 4677-4695

Trigger factor chaperone acts as a mechanical foldase

S Haldar, R Tapia-Rojo, EC Eckels, J Valle-Orero, JM Fernandez

Nature communications 8 (1), 668

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