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Single-molecule covalent magnetic tweezers

Soham Chakraborty, Shubhasis Haldar

Trends in Biochemical Sciences (Technology of the month)

May, 2023

DOI:https://doi.org/10.1016/j.tibs.2023.05.002

Single-molecule force spectroscopy (SMFS) technology enables us to study the heterogeneous nature of the biomolecules that are otherwise inaccessible by conventional ensemble approaches. In particular, magnetic tweezers, a widely-used SMFS technology, exert magnetic force and torque on the single biomolecules and allows us to study their dynamic changes and interactions.

Recent Publications

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DOI https://doi.org/10.1039/D1NR07582A

Elucidating the novel mechanisms of molecular chaperones by single-molecule technologies

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DOI:https://doi.org/10.1016/j.tibs.2023.10.009

Direct observation of chaperone-modulated talin mechanics with single-molecule resolution

Soham Chakraborty, Deep Chaudhuri, Souradeep Banerjee, Madhu Bhatt, Shubhasis Haldar; Nature Communications Biology (IF: 6.4); 2022

DOI: https://doi.org/10.1038/s42003-022-03258-3

Integrin regulated autoimmune disorders: understanding the role of mechanical force in autoimmunity

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DOI: https://doi.org/10.3389/fcell.2022.852878